Beta Glucan is a Licensed drug in Japan
Helping in their fight against Cancer
Beta Glucan Has Shown Great Promise with Psoriasis
Psoiasis may be an Auto Immune problem
Beta Glucan Has Shown Great Promise with Lupus
Beta Glucan "calms" an "over-active" Immune System
Many Are

Maitake Beta Glucan

Shiitake and Cancer
Inhibition of human colon carcinoma development by
lentinan from shiitake mushrooms (Lentinus edodes).
Ng ML, Y ap AT. J Altern Complement Med. 2002 Oct;8(5):581-9.
PMID: 12470439 [PubMed - indexed for MEDLINE]
E_ects of a mushroom mycelium extract on the
treatment of prostate cancer.
deVere White R W, Hackman RM, Soar es SE, Beckett LA, Sun B.
Urology. 2002 Oct;60(4):640-4. PMID: 12385925 [PubMed -
indexed for MEDLINE]
Shiitake and Viruses
A placebo-controlled trial of the immune modulator,
lentinan, in HIV-positive patients: a phase I/II trial.
Maitake & Diabetes
Gordon M, Bihari B, Goosby E, Gor ter R, Gr eco M, Guralnik M,
Mimura T , Rudinicki V , Wong R, Kaneko Y . J Med. 1998;29(5-
6):305-30. PMID: 10503166 [PubMed - indexed for MEDLINE]
Antitumor e_ect of virus-like particles from Lentinus
edodes (Shiitake) on Ehrlich ascites carcinoma in mice.
Takehara M, Mori K, Kuida K, Hanawa MA. Arch Virol. 1981;68(3-
4):297-301. No abstract available. PMID: 7271461 [PubMed -
indexed for MEDLINE]
Maitake and Cancer
E_ect of Maitake (Grifola frondosa) D-Fraction on the
activation of NK cells in cancer patients.
Kodama N, Komuta K, Nanba H. J Med Food. 2003 Winter;6
(4):371-7. PMID: 14977447 [PubMed - indexed for MEDLINE]
E_ects of D-Fraction, a polysaccharide from Grifola
frondosa on tumor growth involve activation of NK cells.
Kodama N, Komuta K, Sakai N, Nanba H. Biol Pharm Bull. 2002
Dec;25(12):1647-50. PMID: 12499658 [PubMed - indexed for
E_ects of maitake (Grifola frondosa) D-Fraction on the
carcinoma angiogenesis.
Matsui K, Kodama N, Nanba H. Cancer Lett. 2001 Oct
30;172(2):193-8. PMID: 11566496 [PubMed - indexed for
Maitake extracts and their therapeutic potential.
Mayell M. Altern Med Rev. 2001 Feb;6(1):48-60. Review. PMID:
11207456 [PubMed - indexed for MEDLINE]
Induction of apoptosis in human prostatic cancer cells with
beta-glucan (Maitake mushroom polysaccharide).
Fullerton SA, Samadi AA, T ortorelis DG, Choudhur y MS, Mallouh C,
Tazaki H, Konno S. Mol Urol. 2000 Spring;4(1):7-13. PMID:
10851301 [PubMed - indexed for MEDLINE]
The use of mushroom glucans and proteoglycans in
cancer treatment.
Kidd PM. Altern Med Rev. 2000 Feb;5(1):4-27. Review. PMID:
10696116 [PubMed - indexed for MEDLINE]
E_ect of Maitake D-fraction on cancer prevention.
Nanba H, Kubo K. Ann N Y Acad Sci. 1997 Dec 29;833:204-7. No
abstract available. PMID: 9616756 [PubMed - indexed for
Activity of maitake D-fraction to inhibit carcinogenesis
and metastasis.
Nanba H. Ann N Y Acad Sci. 1995 Sep 30;768:243-5. No abstract
available. PMID: 8526356 [PubMed - indexed for MEDLINE]
Antitumor activity exhibited by orally administered
extract from fruit body of Grifola frondosa (maitake).
Hishida I, Nanba H, Kur oda H. Chem Pharm Bull (Tokyo). 1988
May;36(5):1819-27. No abstract available. PMID: 3203420
[PubMed - indexed for MEDLINE]
J Med Food. 2012 Oct;15(10):901-8. doi: 10.1089/jmf.2012.0011.
Epub 2012 Aug 8.
Fraction SX of maitake mushroom favorably in_uences blood
glucose levels and blood pressure in streptozotocin-induced
diabetic rats.
Preuss HG, Echard B, Fu J, Perricone NV, Bagchi D, Kaylor M,
Zhuang C.
Department of Biochemistry, Georgetown University Medical
Center, Basic Science Building, 4000 Reservoir Road, NW, Washington,
DC 20057, USA.
Altern Med Rev. 2002 Jun;7(3):236-9.
Can maitake MD-fraction aid cancer patients? Kodama N, Komuta K,
Nanba H. Source, Department of Microbial Chemistry, Kobe Pharmaceutical
University, Kobe, Japan.
Maitake mushroom (Grifola frondosa) MD-fraction containing beta-1,6 glucan
with beta-1,3 branched chains has previously exhibited strong anticancer
activity by increasing immune-competent cell activity.1,2 In this non-random
case series, a combination of MD-fraction and whole maitake powder was
investigated to determine its e_ectiveness for 22- to 57-year-old cancer
patients in stages II-IV. Cancer regression or signi_cant symptom improvement
was observed in 58.3 percent of liver cancer patients, 68.8 percent of
breast cancer patients, and 62.5 percent of lung cancer patients. The trial
found a less than 10-20 percent improvement for leukemia, stomach cancer,
and brain cancer patients. Furthermore, when maitake was taken in addition
to chemotherapy, immune-competent cell activities were enhanced 1.2-1.4
times, compared with chemotherapy alone. Animal studies have supported
the use of maitake MD-fraction for cancer.

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